Understanding the scale
What Is a U-100 Syringe?
A U-100 insulin syringe is calibrated for U-100 insulin, which contains 100 insulin units in every milliliter. On that scale, the line labeled 100 corresponds to 1 mL, 50 corresponds to 0.5 mL, and 10 corresponds to 0.1 mL. The “U” refers to units, while the number identifies the insulin concentration that the syringe scale was designed to match.
When this page converts a U-100 marking to mL, it is using the physical volume relationship printed on that scale. It is not saying that a syringe marking is a universal medication dose. Two solutions can fill the same 10-unit space yet contain completely different amounts of active ingredient because their concentrations differ.
U-40, U-100, and U-500 are not interchangeable labels. U-40 insulin contains 40 units per mL, U-100 contains 100 units per mL, and U-500 contains 500 units per mL. Matching the insulin and delivery device matters because a scale mismatch can create a serious dose error. This U-100 syringe calculator is therefore limited to the U-100 volume scale and must not be used to translate a prescription between insulin strengths.
Ordinary syringes may be marked directly in milliliters rather than insulin units. If the barrel does not clearly say U-100, use the scale and instructions supplied with that device instead of assuming that one printed line equals 0.01 mL.